Mycoplasma hyopneumoniae eradication has been proven to be feasible and highly successful, based on the unique nature of the elimination programs. Regional eradication programs are not required, as research indicates low rates of both lateral transmission and reinfection, even in hog-dense regions. M. hyopneumoniae eradication programs can be adapted and conducted concurrently for the elimination of a second pathogen; for example, porcine reproductive and respiratory syndrome (PRRS) virus.

There are multiple benefits of an M. hyopneumoniae–negative pig flow in the grow-finish phase, including improved average daily gain and feed conversion, and decreased mortality and morbidity. In addition, M. hyopneumoniae–negative status supports the sustainable production of pork through improved animal welfare, improved morale of animal caretakers, and the judicious use of antibiotics, allowing swine practitioners and producers to meet social responsibilities with a proactive approach to improve herd health.