This Roadmap is a practical guide that walks through methods for Mycoplasma hyopneumoniae eradication in the field. To date, various M. hyopneumoniae eradication methods have been described. A deep understanding of successes, best practices for application, potential limitations and causes of failure, are key for proper implementation and development of contingency plans. Here, specific tools and examples are provided based on input from leaders who have aided the advancement of swine health in North America and beyond, and who are willing to share their experience. This is a dynamic tool that will be enriched and updated as new information is generated. Whether a seasoned practitioner or a new graduate, this Roadmap is for you!